JPS6331465B2 - - Google Patents

Info

Publication number
JPS6331465B2
JPS6331465B2 JP54078230A JP7823079A JPS6331465B2 JP S6331465 B2 JPS6331465 B2 JP S6331465B2 JP 54078230 A JP54078230 A JP 54078230A JP 7823079 A JP7823079 A JP 7823079A JP S6331465 B2 JPS6331465 B2 JP S6331465B2
Authority
JP
Japan
Prior art keywords
dihydro
oxo
general formula
quinoline
piperazin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP54078230A
Other languages
English (en)
Japanese (ja)
Other versions
JPS552693A (en
Inventor
Uintaa Uerunaa
Gunaaru Furiibe Uarutaa
Kamupe Uorufuganru
Retsushu Andoroniki
Heningu Uiruherumusu Otsutoo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of JPS552693A publication Critical patent/JPS552693A/ja
Publication of JPS6331465B2 publication Critical patent/JPS6331465B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
JP7823079A 1978-06-23 1979-06-22 1*22dihydrooquinolinee22one derivative*its manufacture and allurgic affection therapeutic drug containing it Granted JPS552693A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782827566 DE2827566A1 (de) 1978-06-23 1978-06-23 1,2-dihydro-chinolin-2-on-derivate und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
JPS552693A JPS552693A (en) 1980-01-10
JPS6331465B2 true JPS6331465B2 (en]) 1988-06-23

Family

ID=6042551

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7823079A Granted JPS552693A (en) 1978-06-23 1979-06-22 1*22dihydrooquinolinee22one derivative*its manufacture and allurgic affection therapeutic drug containing it

Country Status (12)

Country Link
US (1) US4234585A (en])
EP (1) EP0006506B1 (en])
JP (1) JPS552693A (en])
AT (1) ATE224T1 (en])
CA (1) CA1122218A (en])
CS (2) CS207799B2 (en])
DE (2) DE2827566A1 (en])
ES (1) ES481729A1 (en])
HU (1) HU177959B (en])
IL (1) IL57577A (en])
PL (1) PL115260B1 (en])
SU (1) SU831077A3 (en])

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54130587A (en) 1978-03-30 1979-10-09 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
JPS55162774A (en) * 1979-06-06 1980-12-18 Otsuka Pharmaceut Co Ltd Carbostyril derivative
DE3034237A1 (de) * 1979-09-18 1981-04-16 Otsuka Pharmaceutical Co. Ltd., Tokyo Carbostyrilderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende, antihistaminisch wirkende mittel
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
DE3033112A1 (de) * 1980-09-03 1982-04-01 Hochtemperatur-Reaktorbau GmbH, 5000 Köln Atomkernreaktor
JPS57130210A (en) * 1981-02-06 1982-08-12 Kinseishiya Kk Power switch noise remover for audio appliance
US4442111A (en) * 1981-07-25 1984-04-10 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Antithrombotic sulfimino and sulfoximino indolinones-2
DE3225169A1 (de) * 1982-07-06 1984-01-12 Basf Ag, 6700 Ludwigshafen Chinolinderivate, verfahren zu ihrer herstellung, diese enthaltende mikrobizide und ihre verwendung zur bekaempfung von pilzen
DE3434271A1 (de) * 1984-09-19 1986-03-20 Beiersdorf Ag, 2000 Hamburg Substituierte 3,4-dihydro-chinolin-2(1h)-one verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
DE3442570A1 (de) * 1984-11-22 1986-05-22 Hoechst Ag, 6230 Frankfurt Neue substituierte phenylpiperazinderivate, verfahren zu deren herstellung und die verwendung substituierter phenylpiperazinderivate als aggressionshemmer fuer tiere
GB8502267D0 (en) * 1985-01-30 1985-02-27 Pfizer Ltd Quinolone inotropic agents
JPS63119467A (ja) * 1987-10-21 1988-05-24 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
US5006528A (en) * 1988-10-31 1991-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
JP2608788B2 (ja) * 1988-10-31 1997-05-14 大塚製薬 株式会社 精神分裂病治療剤
US5457099A (en) * 1992-07-02 1995-10-10 Sawai Pharmaceutical Co., Ltd. Carbostyril derivatives and antiallergic agent
DE4410822A1 (de) * 1994-03-24 1995-09-28 Schering Ag Neue Piperidin-Derivate
CA2180190A1 (en) * 1995-07-10 1997-01-11 Kazumi Ogata Benzylpiperazine derivatives
GB0203778D0 (en) * 2002-02-18 2002-04-03 Glaxo Group Ltd Compounds
CN100497325C (zh) * 2004-04-21 2009-06-10 齐鲁制药有限公司 哌嗪衍生物及其在制备喹啉酮衍生物中的用途
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
CN101538252B (zh) * 2008-03-20 2011-04-20 成都康弘药业集团股份有限公司 阿立哌唑的制备方法及其中间体
NZ603076A (en) 2010-08-24 2014-12-24 Otsuka Pharma Co Ltd Suspension and cake composition containing carbostyril derivative and silicone oil and/or silicone oil derivative
CA2872883A1 (en) * 2012-05-09 2013-11-14 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof
CN109180577B (zh) * 2018-10-15 2021-11-16 迪嘉药业集团有限公司 一种阿立哌唑的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH523899A (de) * 1968-07-05 1972-06-15 Cassella Farbwerke Mainkur Ag Verfahren zur Herstellung von Derivaten des 2-Oxo-1,2-dihydro-chinolins
JPS517672B2 (en]) * 1972-04-13 1976-03-10
DE2337461A1 (de) * 1973-07-24 1975-02-06 Boehringer Mannheim Gmbh Neue indolderivate und verfahren zu deren herstellung
GB1501149A (en) * 1975-07-11 1978-02-15 Nisshin Flour Milling Co Isocarbostyril derivatives
JPS54130587A (en) * 1978-03-30 1979-10-09 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
JPS55124766A (en) * 1979-03-20 1980-09-26 Otsuka Pharmaceut Co Ltd Antihistaminic

Also Published As

Publication number Publication date
SU831077A3 (ru) 1981-05-15
CS207798B2 (en) 1981-08-31
IL57577A (en) 1982-03-31
PL115260B1 (en) 1981-03-31
HU177959B (en) 1982-02-28
EP0006506A1 (de) 1980-01-09
JPS552693A (en) 1980-01-10
DE2960820D1 (en) 1981-12-03
IL57577A0 (en) 1979-10-31
EP0006506B1 (de) 1981-09-16
CA1122218A (en) 1982-04-20
CS207799B2 (en) 1981-08-31
US4234585A (en) 1980-11-18
ATE224T1 (de) 1981-10-15
PL216409A1 (en]) 1980-03-24
DE2827566A1 (de) 1980-01-10
ES481729A1 (es) 1980-03-01

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